제목: Anti-Atherogenic Effect of Stem Cell Nanovesicles Targeting Disturbed Flow Sites

링크: https://onlinelibrary.wiley.com/doi/10.1002/smll.202000012

소개: 본 연구에서는 동맥경화의 예방 및 치료를 위해 동맥경화의 초기 발병 부위인 혈류 와류 부위를 표적할 수 있는 줄기세포 유래 나노 물질을 개발하였음. 해당 줄기세포 물질에 부여한 병변 표적기능과 더불어 항염증 및 조직재생 기능을 이용해 마우스, 돼지 동물모델에서 그 진단 및 치료 효능을 입증하였고, 인간 세포를 이용한 장기칩(organ-on-a-chip) 모델에서 인체 적용 가능성을 제시함으로써 동맥경화 치료제로서의 새로운 패러다임을 제시함.