Korea Institute of Science and Technology, 생물공학과(석사)
Ohio State University, 병원미생물학 및 면역학과(박사)
Dana Farber Cancer Institute, Harvard Medical School(선임연구원)
중앙대학교 생명공학대학 시스템생명공학과 교수
주요 연구 분야
1 리트로바이러스와 세포의 상호작용
- 리트로바이러스 integrase의 특성 연구
- 리트로바이러스 integrase와 상호작용하는 세포인자 규명
- HIV-1인테그라제를 이용한 에이즈 억제약물 개발
2 세포 독성 유발 화합물들의 독성작용 기전
- 세포 자살 탐지 시스템을 이용한 항암제 연구
- 열처리 사포닌의 암세포 자살 유발 작용
- SV40 바이러스 topoisomerase를 이용한 항암제 연구
보유 기술 자산
논문
Chromone and chromanone derivatives as strand transfer inhibitors of HIV-1 integrase. Arch. Pharm. Res. 31(1), 1-5, 2008.
Statistical Optimization of Growth Medium for the Production of the Entomopathogenic and Phytotoxic Cyclic Depsipeptide Beauvericin from Fusarium oxysporum KFCC 11363P. J. Microbiol. Biotechnol. 18(1). 138-144, 2008
Cytotoxicities of enniatins H, I, and MK1688 from Fusarium oxysporum KFCC 11363P. Toxicon 51, 1178-1185, 2008.
Functional nucleotides of U5 LTR determining substrate specificity of prototype foamy virus integrase. J. Microbiol. Biotechnol. 18(6), 1044-104, 2008.
Characterization of nuclear localization signals of the prototype foamy virus integrase. J. Gen. Virol. 89, 1680-16, 2008.
Apoptosis induced by enniatins H and MK 1688 isolated from Fusarium oxysporum FB1501. Toxicon 53, 723-728, 2009.
Beauvericin and enniatins H, I, and MK 1688 are new potent inhibitors of HIV-1 integrase. J. Anitibiotics 62, 687-690, 2009.
D. H. Lee, U. Hyun, J. Y. Kim, and C.-G. Shin. 2010. Characterization of biochemical properties of feline foamy virus integrase. J. Microbiol. Biotechnol. 20(6), 968-973, 2010.
Increased expression of apoptotic genes in cancer cells by heat-processed crude saponin. Mol. Cell. Toxicol. 7, 7-13. 2011.
Minimal size of prototype foamy virus integrase for unclear localization. Acta Virologica 55, 169-174, 2011.
Gene expression profiling associated with treatment of positive charged colloidal silica nanoparticle in human neuroblastoma cells. Biochip J.